Reverse Oxidative Stress with Redox Signalling

Revers-Oxidative-Stress

We have always believed that our health and wellbeing are a result of the symphony played by our organs working together in harmony. Under the direction of the brain, the conductor, our body creates the magical melody of human wellness. But with scientific advances, we have now gained evidence on the dominant role played by genetic expressions and the critical information carried by the messaging services to make them work. True magic really happens at a cellular level. But how does it all happen? Is there a way to reverse oxidative stress?.

But first… let’s understand what happens at the cellular level

One of the key elements of a typical cell is mitochondria. Mitochondria is a complex structure within the cell and it even has its own DNA. Every cell within the body, except red blood cells, has mitochondria. One of the main functions of mitochondria is energy production. In this role, you can imagine it to be the powerhouse of the cell. Its main role is to convert Adenosine Di-Phosphate (ADP) to Adenosine Tri-Phosphate (ATP) and in the process release energy. This process helps us to do everything that needs energy, right from pressing our fingers on a keyboard to running and exercising. 

There is no doubt that what mitochondria do is essential to our survival. But every single time, the mitochondria produce ATP, it also releases Redox signalling molecules. We knew  for a long time but Redox signalling molecules since long have been discarded as nothing but a waste product. Turns out, it is anything but a waste product. In fact, they are the “fountains of youth”.

Let’s understand Redox signalling molecules deeper

The phrase comprises of the word “Redox” and “signalling molecules”. Let’s take them one at a time. Redox (short for reduction-oxidation reaction) is a chemical reaction in which the oxidation states of atoms (building blocks of a molecule) are changed. Any such reaction involves both a reduction process and a complementary oxidation process, two key concepts involved with electron transfer processes. In short, they affect chemical transformation which involves the transfer of an electron.

Signalling molecules, on the other hand, are molecules that cells use to “talk” to each other by a process called cell signalling. This allows the cells to cooperate and coordinate to make complex physiological processes possible.

One of the important roles of cellular signalling is a genetic expression by stimulating genetic pathways. Not the kind of gene expression that dictates how tall you are or which parent you look like, though that is, of course, a part of genetics. The gene expression pathways we’re talking about right now are the communication lines that carry life-sustaining instructions from our genes to our cells. The cells can then carry out these instructions and keep us alive and healthy.

Cell signalling molecules have been demonstrated to benefit gene expression pathways in the following body systems –

  • Immune System
  • Hormone Modulation
  • Inflammatory Response
  • Digestive Function
  • Musculoskeletal Health
  • Cardio Vascular Health
  • Endocrine (Hormonal) Health
  • Skin Health
  • Brain / Nerve Health
  • Digestive Health
  • Respiratory Health

So, what exactly is Redox Signalling?

Redox signalling is one of the processes by means of which cells send and receive chemical instructions among each other. This enables the cells to work together, making complex physiological phenomena like movement, vision, digestion, etc. possible. Redox signalling is so vital to our being that if it gets disrupted, many of our physiological processes would start failing almost immediately.

Redox signalling molecules are produced within every cell in our body which acts as either cellular activators (Reduced Species or RS) or cellular messengers (Reactive Oxidative Species or ROS).

Cellular Activators (Reduced Species or RS)

Let’s have the same exercise again. In the word “Reduced Species”, “reduced” denotes the state of the activator. This “reduced” state of this species helps in “activating” antioxidants. While the word “species” denotes the variety of molecules that “activate” antioxidants. The activator molecules carry the messages that tell your cells to activate antioxidants stored in your body. Please note that no amount of additional antioxidant, whether natural or supplement can produce the desired effect, unless “activated”. 

Antioxidants are chemicals (both naturally occurring and man-made) that keep free radicals in check. Free radicals are positively charged and chemically unstable particles who are in dire need to bind themselves to anything they lay their hands on by stealing an electron. This is bad for biological systems such as ourselves as free radicals can enter our cells and randomly bind to any biomolecule, causing oxidation.

In an ideal scenario, a cell should be able to produce enough cellular activators or RS to “activate” sufficient antioxidants to neutralize free radicals. An absence of this would lead to oxidative stress or cellular damage. Depending upon which cell is compromised and how high the damage is, the result could be any ailment ranging from mild inflammation to even cancer (in case of compromise to the genetic structure).

Cellular Messengers (Reactive Oxidative Species or ROS)

Reactive Oxidative Species or ROS are in a way free radicals themselves but with a very different role. As the name suggests, these are oxidizing agents who act messengers to the immune system. Without ROS, our body’s immune system has no mechanism to identify oxidative stress or a localized problem it should address. An abundance of ROS in a cellular vicinity indicates “time to act” to the immune system. These Messenger molecules are responsible for enabling proper cell communication within our body to ensure the optimal performance of the immune system. They activate our body’s immune system to protect against bacteria, viruses, and infection.

Wellness is a result of Pro-oxidant and Antioxidant Balance

Our health depends on the balance between oxidative stress and antioxidant defenses. Oxidative stress creates an imbalance between pro-oxidants and antioxidant systems in our body. An imbalance can be a result of several environmental factors. Some of them could be exposure to pollutants, infections, poor diet, toxins, and radiation. To counter this, our body utilizes redox signalling to communicate and to help maintain a healthy balance between pro-oxidants and antioxidants.

Redox signalling molecules regulate our immune system

Redox signalling molecules support crucial immune system functions, as well as cell renewal and healing at every age. They play very crucial roles in:

  • killing pathogens inside the body by destroying infected body cells 
  • triggering and shaping the immune response of the body against infections
  • initiating and regulating cellular repair and restoration

Redox signalling is responsible for maintaining our health and wellness at the molecular level. Without it, life wouldn’t have been possible at all! However, our ability to utilize redox molecules becomes less efficient as we age. Science shows that our diets, our environment, or just getting older can actually turn off genes or lower their activity (downregulation) in the body.  The genes which are responsible for redox signalling in our body are also downregulated. Thus, as we age, stress and environmental toxins inundate our lives and weaken our defenses.  The effect on each individual could different, even under similar environmental and socio-cultural factors due to a variety of reasons. But the result is always detrimental and it shows through a variety of health ailments. 

Bio-Individuality and Redox Signalling

An individual’s cell redox potential affects the bio-mechanism of the gene expression. In other words, with efficient redox signalling, genes can express the necessary molecules for homeostatic balance by either replacing, recycling, or repairing a damaged cell. 

The importance of this cannot be overstated: cellular redox signalling processes enable the cells to detect the damage, and start the repair and replace mechanisms in the mitochondria, including autophagy and apoptosis .

Due to various environmental and genetic factors, each one of us starts developing our own bio-individual patterns of redox signalling and methods to reverse oxidative stress. These unique patterns may lead to various kinds of health concerns ranging from premature aging, skin ailments to diabetes, heart diseases and even cancer. Thus, creating environmental of wellbeing for our redox molecules could be a potential weapon in the armory. 

 

Recommended Posts

  • Skip Stein
  • 597 read
How Plant-Based Diet Helped ...

Almost 10 years ago, we went ‘cold turkey’, adopting a plant-based diet....

Read Article
  • Skip Stein
  • 591 read
Fad Diets – Why ...

Every day there seem to be some new ‘fad diets’ that will...

Read Article
  • Rohit Singh Panwar
  • 360 read
Understanding the Concept of ...

Rather than blindly following any of the fad diets for a short...

Read Article
  • Rohit Singh Panwar
  • 539 read
Is Coffee Good or ...

Coffee is world's favourite beverage. The health effects of consuming coffee is...

Read Article
  • YS Content Team
  • 618 read
Understanding and Managing Lactose ...

Lactose intolerance is a digestive disorder where the body is unable to...

Read Article
  • Barsha Dey
  • 919 read
How does the sumptuous ...

Love Indian food? Yes, so do we! But, is your diet meeting...

Read Article
  • Rohit Singh Panwar
  • 654 read
The Importance of Hormonal ...

An imbalance of hormones in your body can affect its normal functioning....

Read Article
  • Rohit Singh Panwar
  • 1109 read
Why Good Sleep is ...

We all have some sense of the relationship between our sleep and...

Read Article
  • Charu Agarwal
  • 883 read
Understanding Stress for its ...

STRESS is such a trendy word used these days, isn't it!   ...

Read Article
  • Anitha Narayanamurthy
  • 745 read
How to Stay Healthy ...

I often come across clients asking me "Do you think it's a...

Read Article
  • Kanupriya Khanna
  • 723 read
Importance of Nutrition and ...

We live in a time when our children face tremendous academic pressure....

Read Article
  • Kshemina Mhaskar
  • 975 read
Alcohol Free Breastmilk – ...

I have come up with a calculator, with support from my team,...

Read Article
  • Monia Caramma
  • 934 read
Gut Nutrition for a ...

A healthy gut is key for breaking down the food we eat...

Read Article
  • YS Content Team
  • 610 read
6 Interesting Facts About ...

The importance of gut health is often neglected. Your gut does so...

Read Article
  • YS Content Team
  • 128 read
Diabesity: The Twin Epidemics ...

According to statistics, approximately 425 million adults in the age group of...

Read Article
  • Anitha Narayanamurthy
  • 752 read
10 Ways To Sleep ...

A few years back after the birth of my second child, I...

Read Article
  • Skip Stein
  • 530 read
The End of Meat ...

“The problem is that humans have victimized animals to such a degree...

Read Article
  • Kshemina Mhaskar
  • 921 read
Are ayurvedic tonics safe ...

While breastfeeding, we take utmost care to avoid alcohol, but in spite...

Read Article
  • YS Content Team
  • 381 read
5 Simple Diet Tips ...

Losing pounds doesn't have to be torturous. Often, people believe that crash...

Read Article
  • Harshita Dilawri Sachdeva
  • 611 read
How to make Midnight ...

It’s midnight… and are you craving for food? Do you feel like...

Read Article
  • YS Content Team
  • 708 read
Intermittent Fasting for Weight ...

According to the ancient Indian system of medicine, Ayurveda, people should mend...

Read Article
  • YS Content Team
  • 664 read
Are Artificial Sweeteners Safe? ...

The notion is artificial sweeteners are "sugar-free" and a must-have for diabetics....

Read Article
  • YS Content Team
  • 646 read
Circadian Rhythm: Your Body’s ...

Have you ever wondered why you feel sleepy or energetic or with...

Read Article
  • Aastha Jessica
  • 622 read
Keto Diet and Weight ...

Metabolic diseases and obesity have become the world's biggest health issues. According...

Read Article
  • Charu Agarwal
  • 580 read
How to develop a ...

Body image is the perception of a person about his/her physical body...

Read Article
  • Aastha Jessica
  • 147 read
The Origin of The ...

The ketogenic diet is a high-fat, adequate protein, and a low-carbohydrate diet....

Read Article
  • Vikraman V
  • 355 read
What is Visceral Fat ...

Body fat can be of several types, each with their own unique...

Read Article
  • Aastha Jessica
  • 562 read
Menopause Side Effects, Causes ...

Menopause is a natural decline in the reproductive hormones when a woman...

Read Article
  • YS Content Team
  • 707 read
3 Reasons Why Your ...

Since the past few years, ketogenic diets or keto diets are popular...

Read Article
  • Kshemina Mhaskar
  • 900 read
Alcohol and Breastfeeding: All ...

“Is it safe to drink when pregnant? Are you serious? You are...

Read Article
  • Skip Stein
  • 533 read
Health is Wealth and ...

How many successful people, the rich and famous, the leaders of Nations,...

Read Article
  • YS Content Team
  • 746 read
7 Dietary Tips To ...

Our gut is a house to millions of microbes. The gut microbiome...

Read Article
  • YS Content Team
  • 367 read
Ketogenic Diet For Indian ...

Maybe you’ve heard the term “keto diet” a lot from health freaks...

Read Article
  • YS Content Team
  • 655 read
Importance of Healthy Gut ...

Our gut is responsible for putting our body into working order as...

Read Article
  • Rohit Singh Panwar
  • 388 read
Busting the Myth around ...

There are several misconceptions about . Everyone seems to have their own...

Read Article
  • YS Content Team
  • 420 read
Air Purifying Plants – ...

According to the World Health Organization (WHO), air pollution causes 7million deaths...

Read Article
  • Barsha Dey
  • 491 read
Is Sitting the New ...

Sedentary lifestyle habits are currently being associated with the risk of diseases....

Read Article
  • YS Content Team
  • 336 read
Paleo Diet: How It ...

The food humans have subsisted on for most of our history is...

Read Article
  • Barsha Dey
  • 686 read
Air Pollution and You: ...

We are all familiar with the term pollution and always hear about...

Read Article
  • Monia Caramma
  • 795 read
Improve Digestion Naturally – ...

We all face some sort of digestive issues every now and then....

Read Article
  • Rohit Singh Panwar
  • 1372 read
BLUE ZONE diet: The ...

Do you want to live longer, healthier and happier? Is this possible?...

Read Article
  • YS Content Team
  • 536 read
Fennel seeds: The Healthy ...

Have you ever wondered why many restaurants serve fennel seeds at the...

Read Article
  • Barsha Dey
  • 723 read
Is A2 milk really ...

These days A2 milk popular as a healthier alternative to regular milk....

Read Article
  • Barsha Dey
  • 613 read
Prostate Health: How can ...

Do you worry about your prostate health? Are you at a higher...

Read Article
  • Dr. Swapan Banerjee
  • 492 read
Fight Fatigue by Modifying ...

Do you feel constant fatigue all day round? Do the simplest of...

Read Article
  • Gagandeep Singh Mithoo
  • 1102 read
Exercise, Diet and Balancing ...

Without pain, there is no gain. The road to success and accomplishment...

Read Article
  • Barsha Dey
  • 608 read
5 Healthy Herbal Teas ...

Herbal teas are gaining immense popularity in India for its different array...

Read Article
  • Rohit Singh Panwar
  • 1178 read
Obesity and Insulin Resistance: ...

As per WHO, in 2016, more than 1.9 billion adults, 18 years...

Read Article
  • YS Content Team
  • 749 read
Glycemic Index: A Valuable ...

Different foods affect our blood sugar levels differently. Some foods increase our...

Read Article
  • Barsha Dey
  • 918 read
Caffeine vs. Decaffeinated – ...

The importance of Coffee is immense in many of our lives. Many...

Read Article
  • Kanupriya Khanna
  • 826 read
Healthy Foods for Breastfeeding ...

After childbirth, most mothers can produce a healthy supply of breast milk...

Read Article
  • Charu Agarwal
  • 784 read
How To Deal With ...

Stress is bad and stress reduction should be among your top priorities...

Read Article
  • YS Content Team
  • 416 read
Is Coconut Oil Pure ...

Coconut oil had been touted as a "health-food" all across the world...

Read Article
  • Barsha Dey
  • 889 read
A Vegetarian’s Guide to ...

Proteins are essential for your body's growth and maintenance. However, a protein-rich...

Read Article
  • Prof.V.G.K. Murthy
  • 923 read
Moringa: Nature’s Ultimate Superfood ...

Moringa leaf is a nutrient powerhouse packed with more than 90 nutrients...

Read Article
  • Rohit Singh Panwar
  • 1362 read
Improved Gut Health: A ...

“All disease begins in the gut.” – Hippocrates Hippocrates emphasized on gut...

Read Article
  • Rohit Singh Panwar
  • 1109 read
Health And Nutrition For ...

Ever wondered how can we simplify and describe health and wellbeing in...

Read Article
  • Rohit Singh Panwar
  • 1795 read
Prebiotics and Probiotics – ...

"If there's one thing to know about the human body; it's this: the...

Read Article
  • Barsha Dey
  • 877 read
5 Foods that Help ...

Do you feel drowsy the entire day but you just cannot seem...

Read Article
  • YS Content Team
  • 783 read
Ketogenic Diet: Is it ...

Towards the fall of 2016, popular stand-up comedian and AIB cofounder Tanmay...

Read Article
  • Barsha Dey
  • 786 read
The Raging Debate Over ...

A part of the science community strongly believes that genetically modified crops...

Read Article
  • Barsha Dey
  • 904 read
Single Cell Protein: Next ...

In developing countries like ours, food scarcity is one of the major...

Read Article
  • Barsha Dey
  • 674 read
10 Anti-Inflammatory Foods You ...

Inflammation is the immune system’s natural response to stress, toxins, injuries and...

Read Article
  • Barsha Dey
  • 868 read
8 Best Foods for ...

A staggering number of people across the globe experience hair loss. Hair...

Read Article
  • Barsha Dey
  • 694 read
To juice or not ...

As a kid, I always cringed at the thought of eating fruits...

Read Article
  • Barsha Dey
  • 836 read
Why Are Trans Fats ...

We all love our deep-fried junk food. Fried foods are rich in...

Read Article

Post your Comments

NAME *
EMAIL *